Primary structure of an amyloid prealbumin variant in familial polyneuropathy of Jewish origin.
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چکیده
منابع مشابه
A variant of prealbumin from amyloid fibrils in familial polyneuropathy of Jewish origin
Amyloid fibrils were isolated from spleen and thyroid obtained at autopsy from one patient (S.K.O.) of Jewish origin with familial amyloidotic polyneuropathy. Gel filtration on Sephadex G100 after solubilization in 5 M guanidine HCl yielded three major components with 14,000, 9,000, and 5,000 mol wt, respectively. The two larger components shared antigenic determinants with human prealbumin. Am...
متن کاملBrief Definitive Report A VARIANT OF PREALBUMIN FROM AMYLOID FIBRILS IN FAMILIAL POLYNEUROPATHY OF JEWISH ORIGIN* BY MORDECHAI PRAS,:~
Amyloidosis constitutes a heterogeneous group of diseases characterized by the deposition of proteinaceous material composed mainly o f fibrils having a fl-pleated sheet configurat ion (1). The nature of some of these deposits has been clarified in recent years, and it has been shown that under appropr ia te conditions a n u m b e r o f proteins can form fibrils that exhibit the histologic and ...
متن کاملAmyloid fibril protein related to prealbumin in familial amyloidotic polyneuropathy.
Amyloid fibrils were concentrated from the kidney, thyroid, and peripheral nerve of six patients with familial amyloidotic polyneuropathy (FAP). The fibril concentrates were solubilized in 6 M guanidine.HCl and fractionated on Sephadex G-100 columns. The elution profile of all FAP amyloid fibril concentrates revealed a protein of apparent Mr of 14,000, designated the FAP protein, that was absen...
متن کاملPrimary structure of an amyloid prealbumin and its plasma precursor in a heredofamilial polyneuropathy of Swedish origin.
Prealbumin from an individual with heredofamilial amyloid polyneuropathy of Swedish origin was isolated from plasma by using a three-step procedure involving ion exchange, Affi-gel Blue affinity chromatography, and gel filtration. This prealbumin and its associated amyloid fibril subunit protein were digested with trypsin and the resulting peptides were separated by high performance liquid chro...
متن کاملAmyloid fibril protein in familial amyloidotic polyneuropathy, Portuguese type. Definition of molecular abnormality in transthyretin (prealbumin).
Amyloid fibril protein in patients with familial amyloidotic polyneuropathy is known to be chemically related to transthyretin (TTR), the plasma protein that is usually referred to as prealbumin. A genetically abnormal TTR may be involved in this disease. Studies were conducted on amyloid fibril protein (AFp) isolated from tissues of two Portuguese patients who died with familial amyloidosis, a...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1983
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.80.2.539